WHY AVOGEN


Avogen is unique in nature and found only in avocado. We have isolated the key avocado plant chemistry, dubbed it Avogen and made it available in convenient all natural capsule form.

Avogen made the avocado famous for beautiful skin, hair and nails. And now we know it does even more than that. Avogen is a lipid (an oil) that keys on the extracellular matrix. This is what surrounds every cell in our bodies. It is essential to all communication between cells and as we age it deteriorates. Poor communication in and around cells translates into many problems. Few if any compounds developed by man or nature directly address the extracellular matrix. Avogen does.


We focus on avocado because it has yet to undergo the genetic erosion from intensive and selective crossbreeding that other botanicals like soybean have experienced. The natural immune system of the avocado produces many phyto-nutrients whose value we only now begin to understand. Avogen is the highlight of this amazing rainforest superfood.

As you see the benefits of Avogen unfold over time. the experience is wholly different than any other supplement you have tried. In addition to greatly enhanced look to the skin, thick full hair and better nails, the stiffness associated with aging joints softens. More than that, the stiffness around breast implant areas and from surgeries of the abdomen fades and softens to natural state.

Old scars and annoying cysts dissolve and smooth out. You also feel better, younger with more vitality. You think more clearly, concentrate easier. Many tell us even their vision is improved.

Avogen is well tolerated, safe and at one capsule per day will provide all the essential avocado you will need to look great and feel better.





For those who can’t get their daily avocado - there’s Avogen!



UNDERSTANDING THE EXTRACELLULAR MATRIX (ECM)


The ECM is composed of an interlocking mesh of fibrous proteins and glycosaminoglycans and a basement membrane on which epithelial cells rest. What does that mean? A way to visualize this is to picture cells as floating islands and the sea they float in as the extracellular matrix or ECM.

The sea in the case of ECM is like a jelly that supports the islands and sends messages back and forth to the other islands.

The ECM is a dominant feature of our bodies – bone, skin, organs – the cells that comprise these are all surrounded by ECM.

This matrix is very important to the way we look and feel and as we age or are under health stress the ECM deteriorates in quality and quantity. As a result, cells themselves lose their proper structures and the communications between cells break down.

In the case of skin, the tone becomes uneven and waste product builds up in the ECM. The loss of ECM functionality results, for example, in thin skin that is inelastic and resembles crepe paper. Inside the body, the deterioration of ECM affects organs like eyes where vision is impaired or lungs where inelastic ECM leads to reduced respiration efficiency. In fact, every facet of the body can be adversely affected by deterioration of the extracellular matrix.

As the extracellular matrix goes wrong, it is characterized by excess cross-linking. Imagine various strings of fiber that have formed into rope-like strands – these are the collagen proteins of the ECM and as we age or are under environmental stress, the rope-like strands form knots and begin to bind up with other strands and the jelly-like substance between the strands (glycosaminoglycans) gets displaced by these over-crosslinked strands. The result is an inelastic tissue, thin and uneven. Aged skin for example might be described as one large sheet of very thin scar tissue.

In simple trauma of the skin, or internally, scar tissue forms as a mass of excessively crosslinked fibers. In one sense, the body has put up a wad of tissue in short order to protect vital organs. A way to think of this is like sand-bags to prevent a flood of unwanted invaders.

So, there are both natural and environmental causes of crosslinking excesses.

One of the key mechanisms that is in charge of keeping things in order in the extracellular matrix is a phenotype called lysyl oxidase. It organizes and shapes the extracellular matrix and has a lot to say about the communications between cells in the matrix. There are many key signaling functions that occur in the extracellular matrix and it is an area of great interest for understanding medical problems that occur as we age or from trauma.

Avogen supports the key mechanisms involved in regulating normal ECM activity and the result for you is quite simple and very important – you look younger and feel better.


EXTRACELLULAR MATRIX (ECM) LINKS

http://jcb.rupress.org/content/196/4/395.full
http://en.wikipedia.org/wiki/Extracellular_matrix
http://www.wisegeek.com/what-is-an-extracellular-matrix.htm
http://jcs.biologists.org/content/123/24/4195.full
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/E/ECM.html
http://www.facebook.com/pages/Extracellular-matrix/111801118846105
http://pharmrev.aspetjournals.org/content/61/2/198.abstract
http://informahealthcare.com/doi/abs/10.1080/03008200802143190